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KMID : 1044520240870010022
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Tuberculosis and Respiratory Diseases
2024 Volume.87 No. 1 p.22 ~ p.30
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Immune Evasion of G-CSF and GM-CSF in Lung Cancer
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Park Yeon-Hee
Chung Chae-Uk
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Abstract
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Tumor immune evasion is a complex process that involves various mechanisms, suchas antigen recognition restriction, immune system suppression, and T cell exhaustion.
The tumor microenvironment contains various immune cells involved in immune evasion.
Recent studies have demonstrated that granulocyte colony-stimulating factor(G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) induce immuneevasion in lung cancer by modulating neutrophils and myeloid-derived suppressorcells. Here we describe the origin and function of G-CSF and GM-CSF, particularlytheir role in immune evasion in lung cancer. In addition, their effects on programmeddeath-ligand 1 expression and clinical implications are discussed.
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KEYWORD
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Granulocyte Colony-Stimulating Factor, Granulocyte-Macrophage Colony-Stimulating Factor, Neutrophils, Myeloid-Derived Suppressor Cell, Programmed Death-Ligand 1, Immune Evasion
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